What type of target's loss will significantly contribute to the success of the friendly course of action?

The correct option is the High-Payoff Target, as this type of target is deemed crucial to the enemy's operations and overall effectiveness. By successfully engaging or eliminating a High-Payoff Target, friendly forces can disrupt the enemy's ability to conduct operations and significantly shift the operational balance in favor of friendly forces. These targets often lead to a substantial degradation of enemy capabilities, which is why their loss is strategically prioritized during planning.

While High-Value Targets and High-Value Individuals are important, they do not necessarily guarantee the same level of impact on the enemy's operational effectiveness as High-Payoff Targets. High-Yield Targets, on the other hand, refer to targets that can cause great damage or produce a large effect, but they may not directly contribute to altering the operational landscape in the same way as High-Payoff Targets. Therefore, focusing on High-Payoff Targets is vital for maximizing the success of friendly courses of action.